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 | Volume 12, Number 2 (june_ july 2007) |  | |
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 | Prevalence of Helicobacter pylori Infection in Children with Chronic Immune (Idiopathic) Thrombocytopenic Purpura and Evaluation of Helicobacter pylori Eradication on Platelet Count |  |
 | | Author(s): Arzanian MT, Hamidieh AA *, Gachkar L, Imanzadeh F and Shamsian BSh | | Fellowship in Paediatric Haematology & Oncology, Mofid Pediatric Hospital, Shaheed Beheshti Medical University aahamidieh@yahoo.com | | Study Type: Original | Subject: Medicine | | | Article abstract: | | Background: Recently, the high prevalence of Helicobacter pylori infection has been reported in adult patients with chronic immune (idiopathic) thrombocytopenic purpura. Furthermore, after Helicobacter pylori eradication therapy in such patients, their platelet counts have been observed to increase, suggesting that Helicobacter pylori may be a causative agent of adults’ chronic idiopathic thrombocytopenic purpura. However, there have been only a few reports of this subject in children with chronic thrombocytopenic purpura. The purpose of this study is to determine prevalence of Helicobacter pylori infection in Iranian children with chronic thrombocytopenic purpura and role of Helicobacter pylori eradication in rising platelet count of these patients.
Materials and Methods: This descriptive-clinical trial study was performed in 31 children under 14 years old with chronic thrombocytopenic purpura who attended hematology ward of Mofid paediatric hospital. After determining platelet count, and filling the results patients referred to gastrointestinal ward of the hospital to perform urea breath test for evaluation of Helicobacter pylori infection, then Helicobacter pylori-infected patients who were diagnosed by this test, received eradication therapy using triple therapy regimen (containing Omeperasole, Amoxicillin & Clarithromycin) for 2 weeks and their platelet counts were recorded during the follow up period.
Results: Mean age of the patients was 8.93.2 years old ranging from 3.5 to 14 years old. They were 17 (54.9%) girls and 14 (45.1%) boys. Mean platelet count of the patients was 51.4 34.3 109/ L ranging form 125109/ L to 8109/ L . Mean duration of disease in the patients was 27.720.2 months ranging from 7 to 96 months. Helicobacter pylori infection was found in only 4 children (12.9%) and Helicobacter pylori eradication therapy was not effective
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in rising platelet count to achieve complete or partial remission. Comparing Helicobacter pylori-positive and negative patients, there were no significant differences regarding their age, platelet count and duration of disease.
Conclusion: This study shows that prevalence of Helicobacter pylori infection in children with chronic immune thrombocytopenic purpura is less than that is in adults. Furthermore, we have found that platelet count in Helicobacter pylori-positive children have not been risen after eradication therapy. We suggest that more studies in different gender groups and different zones in the world with more number of samples should be performed, especially in children in order to determine both the exact role of Helicobacter pylori‘s pathogenesis in developing the chronic idiopathic thrombocytopenic purpura and the effectiveness of eradication therapy in rising platelet count in these patients.
| | | Keywords: Chronic immune thrombocytopenic purpura, Helicobacter pylori, | |
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Send citation data to: CiteULike | RefWorks | | Arzanian MT , Hamidieh AA , Gachkar L , Imanzadeh F , Shamsian BSh , Prevalence of Helicobacter pylori Infection in Children with Chronic Immune (Idiopathic) Thrombocytopenic Purpura and Evaluation of Helicobacter pylori Eradication on Platelet Count Pajoohandeh Journal, 2007; 12 (2) :69-78 URL http://www.pajoohande.com/browse.php?a_code=A-10-2-48&slc_lang=en&sid=1 | | |
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